Addison’s disease


 

 

Addison’s disease or primary hyperadrenalism is an endocrine disorder result consequently complete destruction of adrenal cortex and consequently reduced production of glucocorticoid , minerlcorticoid and sex-steroid.

 

Etiology

 

  • Autoimmune destruction of 80%
  • Tuberculosis
  • Surgical removal
  • Malignant infiltration
  • Drugs, amyloid and hemorrhage

 

Clinical features

Symptoms

Weakness

Anorexia

Weight loss

Impotence/amenorrhea

Fever

Depression

 

Signs

 

Postural hypotension

Loss of body hair

 

Investigations

 

Plasma ACTH level

Plasma cortical aldosterone level

Blood glucose

Short and long ACTH stimulation level

 

Treatment

Treat the underlying cause in adrenal cortex and use the following drug therapy

 

Glucocorticoids

Cortical 30 mg/daily

Prednisolone 7.5mg /daily

Dexamethasone .7 mg /daily

 

Mineralocortoid

 

Fludrocorticoid .005 -.04 mg/daily